Endocrine Abstracts

Ordinary complication of pregnancy is shift of hepatic excretory activity leading to cholestasis. Gallstone disease is also predominated in women. Both high prolactin (Prl) concentration and high level of liver prolactin receptors (PrlR) in normal and pregnant women were assumed to participate in obstructive cholestasis development.Using female rat model of hyperprolactinemia combined with obstructive cholestasis we aimed to investigate Prl influence on ...